La extraña historia de amor entre una mujer de 30 años y un hombre de 50 que inexplicablemente comienza a rejuvenecer.
 | Brad Pitt | Benjamin Button |
 | Cate Blanchett | Daisy |
 | Taraji P. Henson | Queenie |
| Jared Harris | Capitán Mike |
| Julia Ormond | Caroline |
| Jason Flemyng | Thomas Button |
 | Tilda Swinton | Elizabeth Abbott |
| Mahershalalhashbaz Ali | Tizzy |
| Rampai Mohadi | Ngunda Oti |
| Phyllis Somerville | Abuela Fuller |
 | Elle Fanning | Daisy; 7 años |
| Madisen Beaty | Daisy; 10 años |
 | Elias Koteas | Monsieur Gateau |
| Edith Ivey | Mrs. Maple |
| Ted Manson | Mr. Daws |
| Myrton Running Wolf | Dennis Smith |
| Richmond Arquette | John Grimm |
| David Ross Paterson | Walter Abbott |
| Faune A. Chambers | Dorothy Baker |
| Donna DuPlantier | Blanche Devereaux |
| Rus Blackwell | Robert Williams |
| Patrick Thomas O'Brien | Dr. Rose |
| Danny Nelson | General Winston |
| Lance E. Nichols | Predicador |
| David Jensen | Médico |
