Las reacciones sociales ante el descubrimiento del SIDA y el tenso trabajo de los profesionales y médicos que lo investigan.
 | Matthew Modine | Dr. Don Francis |
| Alan Alda | Dr. Robert Gallo |
| Patrick Bauchau | Dr. Luc Montagnier |
| Phil Collins | Eddie Papasano |
 | Richard Gere | Coreógrafo |
 | Nathalie Baye | Dr. Françoise Barre |
| Christian Clemenson | Dr. Dale Lawrence |
| David Clennon | Mr. Johnstone |
| Bud Cort | Dueño de Antigüedades |
| David Dukes | Mr. Mervyn Silerman |
| David Marshall Grant | Dennis Seeley |
| Glenne Headly | Dra. Mary Guinan |
 | Anjelica Huston | Dra. Betsy Reisz |
| Ken Jenkins | Dr. Dennis Donohue |
| Tchéky Karyo | Dr. Willy Rozenbaum |
| Swoosie Kurtz | Mrs. Johnstone |
 | Donal Logue | Bobbi Campbell |
 | Steve Martin | El Hermano |
 | Ian McKellen | Bill Kraus |
| Richard Masur | William W. Darrow |
| Dakin Matthews | Phil Burton |
| Lawrence Monoson | Chip |
| Saul Rubinek | Dr. Jim Curran |
| Charles Martin Smith | Dr. Harold Jaffe |
| Jeffrey Nordling | Gaetan Dugas |
 | Stephen Spinella | Brandy Alexander |
| Lily Tomlin | Dra. Selma Dritz |
| B.D. Wong | Kico Govantes |
