En Missouri, durante la Guerra Civil, los granjeros, Frank y Jesse James forman una banda para combatir a los soldados de la Unión, quienes devastan el campo.
 | Wendell Corey | Frank James |
| MacDonald Carey | Jesse James |
| Ellen Drew | Bee Moore |
| Ward Bond | Mayor Marshal Trowbridge |
| Bruce Bennett | Cole Younger |
| Bill Williams | Jim Younger |
| Anne Revere | Mrs. Samuels |
| Edgar Buchanan | Dr. Samuels |
| Lois Chartrand | Mary Bauer |
| Louis Jean Heydt | Charles Ford |
| Robert Bray | Charlie Pitts |
| Stephen Roberts | McGuire |
