Biografía de Margaret Thatcher, primera ministra del Reino Unido entre 1979 y 1990, de ideas conservadoras y mano dura que le granjearon el apodo de 'la Dama de Hierro'.
 | Meryl Streep | Margaret Thatcher |
 | Jim Broadbent | Denis Thatcher |
 | Iain Glen | Alfred Roberts |
 | Harry Lloyd | Joven Denis Thatcher |
 | Anthony Head | Geoffrey Howe |
| Olivia Colman | Carol |
| Richard E. Grant | Michael Heseltine |
 | Roger Allam | Gordon Reece |
| Julian Wadham | Francis Pym |
| Nick Dunning | James Prior |
| Alexandra Roach | Joven Margaret Thatcher |
| John Sessions | Edward Heath |
| Michael Pennington | Michael Foot |
| Susan Brown | June |
| Phoebe Waller-Bridge | Susie |
