Ambientada en la década de 1950 en Chicago, pasea por grandes personajes musicales americanos como Leonard Chess, Muddy Waters ó Elvis Presley.
 | Adrien Brody | Leonard Chess |
 | Jeffrey Wright | Muddy Waters |
 | Beyoncé Knowles | Etta James |
 | Mos Def | Chuck Berry |
| Gabrielle Union | Geneva Wade |
| Columbus Short | Little Walter |
 | Cedric the Entertainer | Willie Dixon |
 | Emmanuelle Chriqui | Revetta Chess |
| Eamonn Walker | Howlin' Wolf |
| Eric Bogosian | Alan Freed |
| Marc Bonan | Keith Richards |
