La historia se centra en la relación de Hitchcock con su mujer Alma Reville (Helen Mirren) durante el rodaje de ‘Psicosis’.
 | Anthony Hopkins | Alfred Hitchcock |
 | Helen Mirren | Alma Reville |
 | Scarlett Johansson | Janet Leigh |
 | Danny Huston | Whitfield Cook |
 | Toni Collette | Peggy |
 | Michael Stuhlbarg | Lew Wasserman |
| Michael Wincott | Ed Gein |
 | Jessica Biel | Vera Miles |
| James D'Arcy | Anthony Perkins |
| Richard Portnow | Barney Balaban |
| Kurtwood Smith | Geoffrey Shurlock |
| Ralph Macchio | Joseph Stefano |
| Kai Lennox | Hilton Green |
| Tara Summers | Rita Riggs |
| Wallace Langham | Saul Bass |
