Una empresa rival de modelos intenta sacar a Derek y a Hansel del negocio.
 | Ben Stiller | Derek Zoolander |
 | Will Ferrell | Mugatu |
 | Penélope Cruz | Montana Grosso |
 | Christine Taylor | Matilda Jeffries |
 | Owen Wilson | Hansel |
| Kristen Wiig | Alexanya Atoz |
| Olivia Munn | |
| Billy Zane | |
| Justin Bieber | |
| Madalina Diana Ghenea | Mujer exótica |
| Fred Armisen | |
| Kanye West | |
| Antonio Te Maioha | Guerrero Maori |
| Lewis Hamilton | |
| Cyrus Arnold | Derek Zoolander Jr. |
| Hal Yamanouchi | Viejo chino |
