Una familia típicamente americana gana un viaje por Europa en un concurso televisivo.
 | Charlie Day [II] | Chad |
| Chris Hemsworth | Stone Crandall |
| Beverly D'Angelo | Ellen Griswold |
 | Chevy Chase | Clark Griswold |
| Leslie Mann | Audrey Griswold |
 | Christina Applegate | Debbie Griswold |
 | Regina Hall | Nancy Peterson |
| Michael Peña | Policía Mexico |
| Kaitlin Olson | Policía Arizona |
| Ed Helms | Rusty Griswold |
| Keegan-Michael Key | Jack Peterson |
| Elizabeth Gillies | Heather |
| Skyler Gisondo | James Griswold |
| Nick Kroll | Policía Colorado |
| Samm Levine | Sam |
| Tim Heidecker | Policía Utah |
| Steele Stebbins | Kevin Griswold |
