Un joven Peter Parker comienza su andadura como el héroe arácnido.
 | Tom Holland [X] | Peter Parker / Spider-Man |
 | Robert Downey Jr. | Tony Stark / Iron Man |
| Donald Glover | Aaron Davis |
| Martin Starr | Mr. Harrington |
| Logan Marshall-Green | Jackson Brice |
 | Marisa Tomei | Tía May |
 | Michael Keaton | The Vulture |
| Zendaya | Michelle |
| Angourie Rice | Betty Brandt |
| Jon Favreau | Happy Hogan |
| Garcelle Beauvais | Doris Toomes |
| Kenneth Choi | Morita |
| Tony Revolori | Flash Thompson |
| Hannibal Buress | Wilson |
| Bokeem Woodbine | Herman Schultz |
| Tyne Daly | Anne Marie Hoag |
| Christopher Berry | Randy |
| Michael Chernus | Phineas Mason |
 | Gwyneth Paltrow | Pepper Potts |
| Stan Lee | Gary |
 | Chris Evans | Steve Rogers / Captain America |
