Revela el secreto de la familia Portokalos, que reunirá a los queridos personajes para otra boda griega aún mayor que la primera.
 | Andrea Martin | Voula |
| John Stamos | George |
 | John Corbett | Ian Miller |
| Rita Wilson | Anna |
| Nia Vardalos | Toula Miller |
| Elena Kampouris | Paris Miller |
| Mark Margolis | Panos |
| Lainie Kazan | Maria Portokalos |
| Ian Gomez | Mike |
| Alex Wolff | Bennett |
| Gia Carides | Cousin Nikki |
| Louis Mandylor | Nick Portokalos |
| Michael Constantine | Gus Portokalos |
| Joey Fatone | Angelo |
| Jayne Eastwood | Mrs. White |
| Kolton Stewart | Clifford |
| Bruce Gray | Rodney Miller |
| Fiona Reid | Harriet Miller |
| Bess Meisler | Yiayia |
| Gerry Mendicino | Taki |
