Nuevas aventuras (esta vez alrededor del mundo) para Rayo McQueen y sus amigos.
 | Owen Wilson | Lightning McQueen |
 | Michael Caine | Finn McMissile |
 | Jason Isaacs | Siddeley / Leland Turbo |
 | Emily Mortimer | Holley Shiftwell |
 | Joe Mantegna | Grem |
| John Ratzenberger | Mack |
| Bonnie Hunt | Sally Carrera |
| Tony Shalhoub | Luigi |
| Cheech Marin | Ramone |
 | Thomas Kretschmann | Zundapp |
| Jenifer Lewis | Flo |
| Larry The Cable Guy | Mater |
| Peter Jacobson | Acer |
 | Eddie Izzard | Sir Miles Axlerod |
 | John Turturro | Francesco Bernoulli |
| Brent Musburger | Brent Mustangburger |
| Franco Nero | Topolino |
| Bruce Campbell [I] | Torque |
| Stanley Townsend | Victor Hugo |
 | Vanessa Redgrave | The Queen / Mama Topolino |
| Brad Lewis | Tubbs Pacer |
| Paul Dooley | Sarge |
| Edie McClurg | Minny |
| Richard Kind | Van |
| Katherine Helmond | Lizzie |
 | John Lasseter | John Lassetire |
